The Pololu USB AVR programmer has been tested under Microsoft Windows XP (Service Pack 3), Windows Vista, Windows 7, Windows 8, and Linux. See Section 5 for limited Mac OS X support.
The programmer’s configuration utility works only in Windows, but this should not be a big problem for Linux users because all the options that can be set in the configuration utility are stored in persistent memory, so you would only have to use Windows when you want to change those parameters, which should be rarely (if ever). The programmer does not require the configuration to program AVRs or to use the TX and RX USB-to-TTL-serial adapter pins.
The SLO-scope application works only in Windows.
The programmer is compatible with a variety of AVR programming utilities for Windows, Linux and Mac OS, including AVRDUDE, AVR Studio 4, AVR Studio 5, and Atmel Studio 6.